Cyclophosphamide (NSC 26271) versus the combination of adriamycin (NSC 123127), 5-fluorouracil (NSC 19893), and cyclophosphamide in the treatment of metastatic prostatic cancer. A randomized trial
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Sequential 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (NSC 79037) and 5-fluorouracil (NSC 19893) therapy of gastrointestinal cancer.
Thirty-six patients with advanced gastrointestinal carcinoma were treated sequentially with full therapeutic doses of l-(2-chloroethyl)-3-cyclohexyl-l-nitrosourea followed by 5-fluorouracil. 5-Fluorouracil could be safely administered at 6 weeks although patients still demonstrated peripheral hematological depression secondary to the earlier l-(2-chloroethyl)-3-cyclohexyl-l-nitrosourea therapy....
متن کاملX-ray-diffraction study and determination of absolute configuration of the anticancer drug S(--)cyclophosphamide (Endoxan, Cytoxan, NSC-26271).
(--)Cyclophosphamide(1) crystallized from tetrachloromethane in the triclinic space group P1 with cell dimensions a = 10.500 (4) A, b = 10.490 (4) A, c = 10.761 (4) A, alpha = 110.0 (2) degrees, beta = 110.0 (2) degrees, gamma = 108.9 (2) degrees. Three molecules are contained in the unit cell. The X-ray analysis was based on diffractometer measurement of 2635 independent reflections and the st...
متن کاملAccelerated versus standard cyclophosphamide, epirubicin and 5-fluorouracil or cyclophosphamide, methotrexate and 5-fluorouracil: a randomized phase III trial in locally advanced breast cancer.
BACKGROUND The purpose of this study was to evaluate the impact of a dose-dense primary chemotherapy on pathological response rate (pCR) in patients with locally advanced breast cancer (LABC) treated with combined modality therapy. PATIENTS AND METHODS Stage IIIA/IIIB patients received three courses of induction chemotherapy (ICT) with cyclophosphamide, epirubicin and 5-fluorouracil (CEF) fol...
متن کاملClinical Investigation of the Physiologic Disposition of a Phthalanilide (nsc-38280) and a Phthalamidine Derivative (nsc-57155) in 7 Patients.
thalanilides (10) in animals (2—7, 9, 13, 15, 20, 21, 24, 28— 31, 33, 34) and tissue culture (12, 23, 32),@clinical trial of these compounds has been described by various investi gators (16—18,22). This report deals with the absorption and excretion of the radioactivity of C'4-labeled 4' ,4―bis(2-imidazolin-2-yl) 2-chloroterephthalanilide dihydro chloride (NSC-38280)4 after P.O. and I.V...
متن کاملthe analysis of the role of the speech acts theory in translating and dubbing hollywood films
از محوری ترین اثراتی که یک فیلم سینمایی ایجاد می کند دیالوگ هایی است که هنرپیش گان فیلم میگویند. به زعم یک فیلم ساز, یک شیوه متأثر نمودن مخاطب از اثر منظوره نیروی گفتارهای گوینده, مثل نیروی عاطفی, ترس آور, غم انگیز, هیجان انگیز و غیره, است. این مطالعه به بررسی این مسأله مبادرت کرده است که آیا نیروی فراگفتاری هنرپیش گان به مثابه ی اعمال گفتاری در پنج فیلم هالیوودی در نسخه های دوبله شده باز تولید...
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ژورنال
عنوان ژورنال: Cancer
سال: 1978
ISSN: 0008-543X,1097-0142
DOI: 10.1002/1097-0142(197812)42:6<2546::aid-cncr2820420607>3.0.co;2-c